SISANews

Le HDL basse rimangono un fattore di rischio anche in corso di terapia con statine

Interessante revisione degli studi di intervento con statine. La conclusione è che se le HDL sono basse, il rischio cardiovascolare rimane elevato anche se i pazienti sono adeguatamente trattati con statine.

Low high-density lipoprotein cholesterol and increased cardiovascular disease risk: an analysis of statin clinical trials

Deedwania P, Singh V, Davidson MH.

Am J Cardiol 2009;104[10 suppl]:3E-9E

It is well established that low high-density lipoprotein (HDL) cholesterol is a risk factor for coronary artery disease (CAD). Growing evidence from epidemiologic as well as intervention studies have identified that a low level of HDL cholesterol contributes to cardiovascular disease risk. In addition, a number of clinical trials have substantiated that an inverse association between HDL cholesterol concentrations and cardiovascular risk exists. Decreasing low-density lipoprotein cholesterol levels with statins has a major impact on cardiovascular risk reduction, and statin therapy plays a significant role in the management of CAD. However, low levels of HDL cholesterol remain as a cardiovascular risk factor despite statin therapy. This article presents an overview of statin clinical trials and discusses implications for the clinical management of patients with low HDL cholesterol levels and increased cardiovascular risk.

Am J Cardiol 2009;104[10 suppl]:3E-9E