Diateca

Bookmark and Share

Progetto vincitore della Borsa di Studio SISA 2016 - Adorni

 

 

Effect of JAK-STAT inhibition on macrophage cholesterol metabolism and atherosclerosis

Maria Pia Adorni

 


Abstract:


Background/Rationale. Systemic inflammatory and autoimmune diseases are associated with accelerated atherosclerosis and increased cardiovascular risk. This link involves monocyte activation, increased macrophage lipid deposition and augmented inflammation in vascular intima. Macrophages counteract cholesterol accumulation by the efflux process (CE), occurring through four main mechanisms and allowing cholesterol transfer to extracellular acceptors, mainly high-density lipoproteins (HDL). In macrophages, cholesterol metabolism and inflammation are strictly linked, contributing to the pathogenesis of atherosclerosis. We and others showed that serum CE capacity (CEC) is impaired in patients with inflammatory and autoimmune diseases and drugs can be differently influence cholesterol metabolism on the macrophage side. The Janus Kinase/signal transducers and activators of transcription (JAK/STAT) pathway is an essential intracellular signaling mechanism regulating inflammatory and immune responses. Recently it has been shown that the induction of JAK/STAT signaling pathway is pro-atherogenic.

Objectives of the project.
The aim of this study is to assess the effect of JAK-STAT inhibition on cholesterol metabolism and inflammatory function in macrophage exposed to serum of healthy subjects and autoimmune patients.

Methods and research strategies.
The effect of JAK-STAT inhibition, obtained with tofaticinib, will be evaluated on: cholesterol efflux, free cholesterol distribution and foam cells formation measured by isotopic techniques, cholesterol accumulation by fluorimetric assay and cytokines secretion using ELISA kits.

Expected results.
The results will contribute to define JAK-STAT signaling pathway


 

 

 

Presentazione del progetto vincitore di Borsa di Studio SISA - 2016

 

 

 


Area Soci

Eventi

33° Congresso Nazionale


33° Congresso Nazionale

Roma, 24-26 novembre 2019
Save the date

[continua a leggere]

EAS Advanced Course in Rare Lipid Disease

Cinisello B.mo (Mi), 19 Ottobre 2018

[continua a leggere]

Congresso Regionale SISA Piemonte-Liguria-Val d'Aosta

Pollenzo, Bra (CN), 13 Ottobre 2018

[continua a leggere]

Congresso Regionale SISA Sezione Campania

Napoli, 11 Ottobre 2018

[continua a leggere]

Congresso Regionale SISA Sezione Lombardia

Milano, 4-6 Ottobre 2018
Assegnati i premi

[continua a leggere]

Giornale Italiano Arteriosclerosi

Rivista in lingua italiana
riservata ai Soci S.I.S.A.
Ultimo numero:
Anno 9 • N.4/2018

[continua a leggere]

Rivista NMCD

Nutrition, Metabolism and Cardiovascular Diseases

Istruzioni per l'accesso online

IF 2017: 3.318


Newsletter

Per essere informati sulle novità di S.I.S.A. iscrivetevi alla nostra newsletter inserendo
il vostro indirizzo di posta elettronica

Progetto LIPIGEN

LIPIGEN
Nuovo sito dedicato al Progetto LIPIGEN

 

Progetto LIPIGEN - Vecchio portale
E' necessario essere loggati come utente
Lipigen per poter accedere alla pagina

PROject Statin Intolerance SISA

 

PROSISA – PROject Statin Intolerance SISA
E' necessario essere loggati come utente
PROSISA per poter accedere alla pagina

GILA - Lipoprotein Aferesi

 

Gruppo Interdisciplinare Lipoprotein Aferesi
(Accesso Gruppo GILA-Lipoprotein Aferesi)

E' necessario essere loggati come utente del Gruppo GILA per poter accedere

 

Gruppo Interdisciplinare Lipoprotein Aferesi
(Documentazione ad accesso libero)

Pagina informativa per medici e pazienti